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pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can minimize panobinostat degrees by ~70% and lead to treatment method failure.pentobarbital will lower the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify The